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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are often characterized as a focus on the practical aspects of study design, including recruitment and consent, adherence and the use of standard equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed a variety of investigators and included participants from different geographical regions. This kind of heterogeneity, which is vital for pragmatic trials to be reliable and to reduce bias in the results is also essential. However, too much heterogeneity can result in problems with the design of the trial.

Pragmatic Play, one of the major players in the live casino market, provides an array of traditional table games such as Blackjack and Roulette. The company's live studios in Romania and Malta offer a real-life gaming experience for its customers and offer a wide range of virtual betting options. The company also has several games which make online gambling enjoyable and engaging. Some of these shows are broadcast live and others feature famous personalities in the industry.

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Pragmatic Play has earned a name for itself by providing top-notch games and an exceptional user experience. The software is available on mobile devices and in a variety of languages. Despite its infancy, it has already established itself as a top gaming platform for casinos. Its latest releases include Wolves which is a five-reel video slot that has a healthy RTP and 프라그마틱 슬롯 체험 슬롯 하는법 (Daoqiao.Net) stunning graphics. The other notable titles include Wolf Gold and Chilli Heat.

The goal of pragmatic trials is to mimic real-life scenarios and gain maximum credibility externally. They are typically commissioned by practitioners and policy makers to aid in their decision-making. They are also a good method to determine the cause-effect relationship between an intervention and its outcomes. However, they should not be used as a substitute for the use of explanation studies.

The pragmatism idea is controversial and there are doubts about whether pragmatic trials can replace tests for explanations or if they should serve as an alternative to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which validate a physiological or clinical hypothesis and pragmatic trials that inform policy and practice decisions. They also suggested the framework for pragmatic trials, called PRECIS.2 This tool sought to define the elements of a practical trial, including the recruitment process, the design and delivery of the intervention, as well as the follow-up.

There is a positive increase in the number pragmatic trials that are published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to controlled trials that are randomized (RCTs) produced 34 articles, shown in red in Figure 2. This is an indication that the health sciences community is becoming increasingly sensitized to the issue of pragmatism. However, it is important to keep in mind that the majority of these studies were conducted in primary care settings.